Safety Assessment of Combination of Tinospora crispa Extract, Andrographis paniculata, Cinamomum burmanii, Syzygium polyanthum dan Momordica charantia in Hepar and Renal Function

Abstract

Tinospora crispa, Andrographis paniculata, Cinamomum burmanii, Syzygium
polyanthum and Momordica charantia contain phenolics and flavonoids
which are rich in benefits. Phenolic compounds are compounds that have an
aromatic ring with one or more hydroxy groups, compounds derived from
plants that have the same characteristics, namely aromatic rings containing
one or more hydroxyl groups. Herbal plants, which are rich in phenolic
compounds, have the efficacy, among others, as antioxidants, anti-
inflammatory, antimicrobial, anti-fungal and prevents tumor growth. The
acute toxicity test is a procedure designed to determine the median lethal dose
of a substance and its possible mechanism of action and target organs. In
simple terms, toxicity can be defined as the ability of a compound that can
cause harmful effects or deviate from the biological mechanism in an
organism.